Toxic fibrillar oligomers of amyloid- have cross- structure
نویسندگان
چکیده
منابع مشابه
Toxic fibrillar oligomers of amyloid-β have cross-β structure.
Although amyloid fibers are found in neurodegenerative diseases, evidence points to soluble oligomers of amyloid-forming proteins as the cytotoxic species. Here, we establish that our preparation of toxic amyloid-β(1-42) (Abeta42) fibrillar oligomers (TABFOs) shares with mature amyloid fibrils the cross-β structure, in which adjacent β-sheets adhere by interpenetration of protein side chains. W...
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Department of Chemistry, Ulsan Nationa (UNIST), Ulsan 44919, Republic of Korea. E Department of Chemistry, Pohang Universit Pohang 37673, Republic of Korea Department of Chemistry, Research Institu Seoul 02841, Republic of Korea. E-mail: hug Graduate School of Medical Life Science, Kanagawa 230-0045, Japan † Electronic supplementary information Fig. S1–S18 and Tables S1 and S2. See DO ‡ These a...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2012
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1203193109